Aspergillosis in Dogs: Symptoms, Diagnosis, and Treatment Guide
Aspergillosis in Dogs: Symptoms, Diagnosis, and Management
Being a pet parent, it is almost a distressing situation to see your dog suffering from an unexplainable respiratory problem and suffering from it for a long time. Most people immediately see a problem that can cause their dog to develop kennel cough or seasonal allergies, but there is a very serious and more sinister environmental problem that you should know about aspergillosis in dogs.
This is an opportunistic fungal infection from a common type of mold, called Aspergillus. Dogs are continually breathing in these microscopic fungal spores, which are found in soil, old compost heaps, dry hay and stable bedding. In a healthy dog the spores are easily neutralized every day, but if the immune system is compromised, the fungus can become established, multiply and continue to affect the body in a localized or systemic manner.
By understanding the development of aspergillosis, being able to recognize the early warning signs, and knowing what diagnostic procedures are likely to be used, you can help to ensure your dog’s future health. This detailed guide covers all the information needed for dealing with this complicated fungal matter.
So, what is Aspergillosis in Dogs?
It is important to familiarize yourself with the different biological types of the condition in order to be able to adequately protect your furry friend. There are two main types of aspergillosis in dogs, depending on the location of the infection in the body.
- Nasal Aspergillosis is by far the most prevalent type of aspergillosis in dogs. The infection is confined to the dog’s nasal passages, frontal sinuses and upper respiratory tract. The fungal growth spreads to form thick “plaques” that actively destroy the fine scroll-like bony structures in the snout called “turbinates.
- Disseminated Aspergillosis This is a much less common form but has a much greater life-threatening potential. In dogs, disseminated Aspergillus is when the fungi invade the respiratory tract completely and enter the blood stream to invade the internal organs systemically. This form usually targets the bones of the skeleton, the discs between the vertebrae of the spine, kidneys, liver and eyes.
What are the highest risk breeds?
It basically can happen to any dog exposed to high levels of spores, but there are some physical characteristics and inherited tendencies that make a dog more susceptible.
- Long nosed dog breeds have a massive internal surface area in their nasal cavity which also serves as an uncontrolled reservoir for fungal spores inhaled into the lungs. Historically, certain breeds, such as German Shepherds, Collies, and Greyhounds are overrepresented in clinical settings.
- Medium nosed dogs like Golden Retrievers and Labradors also experience a fair number of cases, particularly if they are working dogs outdoors and are tracking in soil or vegetation.
- In immunocompromised Canines, dogs with immune system defects or those taking long term steroids, there are no cellular mechanisms in place to permanently suppress aspergillosis in dogs before it becomes established.
- Specific Genetic Vulnerabilities: Interestingly, the German Shepherd breed shows a well documented genetic immunodeficiency for a specific antibody (IgA), thus making them very susceptible to both nasal and disseminated forms of aspergillosis in dogs.
Clinical Symptoms to Watch For
Dogs develop a specific progression of clinical symptoms with localized destruction that are caused by aspergillosis. Pet parents should watch for these warning signs:
- Persistent Nasal Discharge is usually the first sign that something is wrong. Discharge generally starts in one nostril (unilateral) and may spread to both nostrils. It frequently starts with clear fluid and then becomes thick yellow-green slime or even blood (epistaxis).
- The fungal plaques produce intense internal inflammation which is visible and sensitive. Your dog could be pawing at their face, avoiding touching their muzzle when you reach for it or whining as they eat dry kibbles.
- Depigmentation: With the passage of time, the constant inflammation of the discharge will physically wear down the dark pigment around the outside nostrils, leaving the outer edge of the nose raw pink, or flaky white.
- Frequent Sneezing and Reverse Sneezing – The body is constantly attempting to mechanically expel the fungal mats causing uncontrollable sneezing.
- Dogs with the condition may lose their interest in their food bowl entirely due to the discomfort, as well as their loss of smell.
In dogs, if disseminated aspergillosis occurs, you might observe entirely different changes in structure, such as lameness, extreme pain in the back, fever, enlarged joints, and weight loss.
Diagnosis Protocols
Diagnosis is a methodical approach as the symptoms can be confused with other nasal problems such as a foreign body (such as a grass awn inhaled), or a localized cancerous tumor.
Your veterinarian will usually use a combination of specialized tools:
Advanced Imaging (CT Scan or MRI): Computed Tomography (CT) scan is highly preferred. It offers a clear insight into the internal structure of the skull, showing the precise pattern of destruction of the turbinate bones typical of aspergillosis in dogs.
Veterinarians use a small, flexible camera to examine the nose during rhinoscopy while the animal is under general anesthesia. This enables them to see the characteristic white or greyish plaques, which are caused by the fungi.
Rhinoscopy (biopsy, fungal culture): Small pieces of tissue or brushings are taken from the plaques during rhinoscopy and examined under the microscope to confirm the presence of aspergillus organisms.
Serology (Blood Tests): Blood tests can be used to identify specific antibodies to aspergillosis in dogs, but often are combined with imaging to make a definite diagnosis.
Treatment & Surgical Options
When the diagnosis is confirmed, medication (antifungal pills) is not usually effective enough when given by itself because the blood supply is poor inside the nose of a dog with the disease. Rather, the advanced localized treatment is the norm.
A specialized non-surgical technique called a topical infusion is the preferred clinical treatment for nasal aspergillosis in dogs:
- Airway Protection and Anesthesia: Patient Safety
The dog is under deep general anesthesia and an endotracheal tube is inserted and secured by an inflatable cuff. It is an absolute requirement to make sure that liquid drugs do not get accidentally down into the lungs.
- Catheter Insertion and Packing :Targeted Delivery.
Carefully inserted specialized catheters are inserted into the nasal passages and frontal sinuses. Surgical sponges are placed in the back of the throat to form a tight seal around the fluid.
- Liquid Clotrimazole Infusion :Fungal Destruction.
A strong liquid anti-fungal medication (usually 1% Clotrimazole) is sprayed into the nose. This fluid is left in for only one hour, and the patient is turned frequently throughout that hour to make sure that all the inside surfaces of the passages are covered with the medicine.
4.4.Evacuation and Flushing: Procedure Wrap-up.
After an hour, the catheters are removed, all liquid is carefully drained from the nostrils and the dog is safely awakened by flushing out the nostrils with sterile saline.
Although there is a high success rate (about 80%) with a single infusion, in some severe cases of aspergillosis in dogs, a second infusion a few weeks later will be needed to eliminate the infection. The more uncommon distribution type of aspergillosis in dogs, however, is not treated with topical flushing and must be treated for many months with systemic (oral) antifungal drugs, such as itraconazole or voriconazole.
Long-Term Prognosis and Environment Management
The prognosis for nasal aspergillosis in dogs is generally good, as long as the fungus does not have enough time to break through the thin bone wall (cribriform plate) between the nasal cavity and the brain. If this barrier is left in place and the local therapy is effective, most dogs live a normal and active life but with a structurally changed nose inside.
Unfortunately, the outlook is guarded to poor with disseminated aspergillosis because fungal infections are very difficult to cure entirely in deep skeletal tissues and organs in dogs.
The mold spores are a natural part of the outdoor environment, so it is impossible to avoid them completely. You can reduce the risks to the environment by ensuring that your dog does not go in to dusty barns, fresh excavations, or wet rotting leaf or compost heaps.
Conclusion
When faced with a dog diagnosis of aspergillosis, it can be quite a shock, particularly after dealing with advanced imaging and nasal infusion. Very aggressive fungal problem can change your dog’s upper respiratory condition if not treated.
But if you’re paying attention to your pet’s breathing, nasal discharge and comfort level, you’ll be able to take action before major structural damage occurs. With the help of your veterinarian, you can effectively fight back in dogs with aspergillosis, and help your pup live a comfortable and happy life.
Frequently Asked Questions (FAQ)
Q1. Can people catch aspergillosis directly from a dog infected with it?
No. Zoonotic disease is a disease that cannot be directly transmitted from an animal to a human. Aspergillosis in dogs is not a zoonotic disease. The infection is not transmitted between dogs and humans, but rather by breathing the microscopic spores of fungus found in the outside environment.
Q2. Would aspergillosis in dogs be the same as kennel cough?
No. Kennel cough is an upper respiratory infection caused by a particular bacteria or virus (Bordetella) and results in a dry, hacking cough which is very contagious. In dogs, aspergillosis is localized fungus infection that develops in the depths of the nasal passages and frontal sinuses and, mainly, leads to nasal discharge and erosion of the bone, rather than the primary cough.
Q3. How much does it take to apply nasal infusion treatment?
The infusion liquid part of the treatment is directly infused into the nasal passages for just one hour of nasal contact time. But don’t forget the preparation time for general anesthesia, the use of advanced imaging, the time spent on draining the area after the procedure, and the recovery period, your dog will likely spend the whole day in the veterinary hospital.









