Tag: Corticosteroids

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Chronic Bronchitis in Dogs

What is Bronchitis?

Most of us have heard of bronchitis, and most of us have probably suffered from it at some point. The bronchi are the larger airways through which air is moved throughout the lungs. The trachea (windpipe) brings air from the throat down into the chest and branches into two mainstem bronchi, one for each lung. Each mainstem bronchus branches into smaller bronchi, which eventually become smaller structures called bronchioles that, in turn, branch, and re-branch, eventually ending with the alveoli, small chambers where oxygen is absorbed into our bodies from the air we inhale.

Listen to a dog cough. Coughing, reverse sneezing, and retching to vomit are commonly confused. The dog in this video is coughing.

Bronchi are basically tubes made of cartilage, forming the larger “pipes” in our lungs.  

When the bronchi are injured by irritants (cigarette smoke, air pollution, biochemical products of infection, etc.), they respond with a healing process that is inherently inflammatory. When the injury becomes ongoing, the inflammatory/healing process also becomes ongoing and the end result involves excessive mucus production in the airways. The mucus obstructs the smaller bronchi, which stimulates coughing, which in turn leads to irritation and then to inflammation, and then to more mucus. A vicious cycle results.

Once the vicious cycle of mucus production to coughing to inflammation to more mucus has become entrenched, it is unlikely to be cured and therapy is geared towards controlling the symptoms.

What is Chronic Bronchitis?

In order to fit the definition of “chronic bronchitis”, the coughing condition in question must (obviously) be chronic. Bronchitis can be temporary, as in short-term infectious diseases such as Kennel Cough, or it can be chronic, which basically means it just doesn’t seem to go away. To fit the definition of “chronic”, the cough must be present daily for at least two months. Chronic bronchitis is a lifelong condition once it starts; it never fully goes away but can be managed.

The second part of the definition of chronic bronchitis is that the chronic cough condition must include bronchial inflammation. (In other words, chronic bronchitis must be both chronic and bronchitis.) There are many causes of ongoing cough; bronchitis is certainly not the only one. For example, heart disease can cause chronic cough, as can tracheal collapse, and certain types of parasitism or even cancer can cause ongoing coughing. The character of the cough (wet, dry, “honking,” productive, etc.) is not particularly helpful in determining the cause of the cough, as coughing can sound similar regardless of its cause. Diagnostic tests are needed to get the right diagnosis, whether it is bronchitis or something else. It is very important to determine whether or not a reversible underlying cause is present.

Diagnosis and Testing

There are many conditions that make dogs cough chronically, including but not limited to:

  • Pneumonia
  • Tracheal collapse
  • Fungal infection in the lung 
  • Lungworms 
  • Cancer 
  • Heart failure
  • Heartworm infection

Note that asthma is conspicuously missing from this list. Asthma involves recurring episodes of airway inflammation and narrowing rather than continuous (non-episodic) airway inflammation. Asthma is not a natural clinical entity in dogs, though it is certainly a well-described condition in cats.

Chest radiograph of a dog with bronchitis. The heart is the oval structure in the center. The lacy white texture of the lungs comes from mucus and other inflammatory secretions clinging to (and visually highlighting) the airway walls. Image courtesy of MarVistaVet.

Radiographs (X-rays) of the lungs are crucial in ruling out conditions that have a specific treatment. In bronchitis, mucus in the airways tends to outline the shape of the airways in patterns that look like parallel lines (so-called tram lines) when looking at an airway’s side view or circles (so-called doughnuts) when looking at an airway to end on. In bronchitis, the airways may be dilated as well, especially if the case is advanced. Other conditions tend to have characteristic radiographic appearances of their own but there is definitely room for ambiguity.

In a perfect world, bronchoscopy can be performed, and samples of the airway secretions can be analyzed. In bronchoscopy, a small video camera is inserted down the airway system. The color and character of the airway walls can be examined, and a fluid wash can be used to aspirate out secretion samples. General anesthesia is required for this procedure. This YouTube video shows a bronchoscopy and sampling of the airway secretion.

Alternatively, a tracheal wash can be done to obtain samples using tubing and fluid washes. In this procedure, only samples are taken, and there is no camera involved and no visual inspection of the airways. Sedation is generally needed.

Sedation and anesthesia are not without risk in patients with lung compromise, so the benefit of obtaining diagnostic information must be weighed against patient risk. Often invasive procedures are skipped, and trial courses of medication are used.

Treatment

There are several aspects to the treatment of bronchitis. Often a weight loss program relieves so much chest restriction that medications become unnecessary. Physical therapy techniques can be used to clear secretions. Medications can be used to relieve inflammation, dilate airways, and reduce secretions, but some trial and error are often needed to get the right combination.  Newer inhalant therapies can spare the patient many potential drug side effects.

Trial Courses of Medication

Different individuals respond to different medications, and in bronchitis, there are several options to choose from and even combine. 

Corticosteroids

Corticosteroids such as prednisone relieve inflammation and cut secretions as no other medication can. Typically, a short course is used to control symptoms initially followed by a lower dose maintenance course. This helps dry up the mucus in the airways and stop the cough-irritation vicious cycle. The problem is that oral steroids have side effects potential with long-term use. Furthermore, because they are suppressive to the inflammatory process, it is important to rule out infectious causes of coughing that might be made worse with steroid use.

As an alternative to oral steroids, inhaled steroids can be used as is done with human asthmatics. A special facemask is used, and a spacer connects the mask to the metered dose inhaler. A couple of puffs from the inhaler doses the dog with inhaled steroids, and then it is possible to avoid the systemic side effects associated with oral steroids. Dogs typically need to use inhalers at least twice a day to control the symptoms of bronchitis. Airway dilators can also be given via inhalation in the same way as steroids.

Cough Suppressants

The cough itself is involved in the vicious cycle of irritation described above. Suppression of the cough reflex through medication may be helpful in establishing patient comfort. On the other hand, we want our patient to be able to clear the mucus from the inflamed airways if there is an excess of mucus. Common medications used are hydrocodone and butorphanol. Over-the-counter human products are often ineffective and may be combined with harmful additional medications such as decongestants or pain relievers.

Never medicate your pet without checking with your veterinarian first about what product to use and how to dose it.

Airway Dilators

Although airways technically do not constrict in chronic bronchitis, it may be helpful to relax them, allowing air to pass through bronchi that had previously been so small as to be blocked by mucus. Common medications include albuterol, terbutaline, and theophylline.  These are frequently used in combination with corticosteroids to reduce cough.

Mucolytics

An over-the-counter supplement called N-acetylcysteine may be helpful. This supplement works by breaking down sulfur bonds in the airway mucus, creating a more watery secretion. Thinner secretions may be easier to clear. The use of this supplement has not been formally studied for this use but it is an option that might be helpful.

Check with your veterinarian about what to use and how to use it.

Antibiotics?

Chronic bronchitis is not an infectious disease but all the inflammation and mucus in the lung certainly compromises the patient’s normal resistance to infection and ability to clear inhaled bacteria. Sometimes antibiotics are a helpful temporary addition to the therapies listed above.  More commonly, antibiotics are used early in the treatment course to rule out infectious causes of cough before the use of corticosteroids, which are immune suppressive.

Other Therapies

Nebulization and Coupage

It is important for the bronchitis patient to cough up inflammatory secretions as long as coughing does not become excessive and perpetuate the inflammation. It is not easy to draw the line as to when the cough is helpful and when it is excessive; only experience will tell. In patients for whom coughing is encouraged, it may be useful to moisten secretions with a vaporizer or even a nebulizer; the difference in these pieces of equipment is the size of the water droplet they generate. Inhalation of water vapor a couple of times daily will help keep secretions moist.

Coupage is a form of respiratory physical therapy that allows for moistened secretions to be moved into more central airways so they can be coughed up. See a YouTube video of how to do coupage.

Obesity Management

Pressure on the chest from body fat hampers the patient’s ability to take a deep breath. Many patients with chronic coughs do not require medication after excess weight has been lost simply because the chest can then expand properly.

Minimize Airway Irritants

It is especially important to minimize irritants circulating in the air. If possible, cigarette smoking should be limited to outdoor areas. If house painting, cleaning, or remodeling is planned, the pet should probably be boarded or stay elsewhere until any fumes have dissipated. It may be a good idea to get a good air filter for home use to minimize dust, pollens, or molds in the air.

Chronic bronchitis represents an ongoing airway change that generally cannot be cured; however, symptoms are manageable for most patients. Discuss the options for therapy with your veterinarian, expect some trial and error to be necessary, and it is likely the outcome will be a system that keeps your pet comfortable.

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Aural Hematoma in Dogs and Cats

Why is an Aural Hematoma a Problem?

A hematoma is swelling created by a broken blood vessel after bleeding has occurred inside a tissue. Hematomas in the earflaps (aural hematomas) occur when head shaking breaks a blood vessel within the earflap. The earflap may partially or completely swell with blood. The swelling may be so large that the opening of the ear canal is occluded. The extra weight of the earflap may be uncomfortable and may lead to a permanent change in the carriage of the ears. This condition is more common in dogs but can occur in cats as well. The earflap will feel fluctuant and fluid-filled, like a water balloon.

A small hematoma may not actually be a problem and may not require repair. There are several situations where the hematoma should be repaired.

  • The hematoma is so big that the ear canal is occluded (blocked). If this is the case, the ear cannot be evaluated for infection, nor can any infection be treated. In this situation, the hematoma must be relieved before the ear canal can be accessed.
  • The hematoma is in a location where natural healing will create scarring in such a way that the ear canal will be permanently narrowed. A permanently narrow ear canal can predispose the patient to a lifetime of ear infections. This is particularly a problem in cats.
  • The hematoma should be repaired if the owner feels the heavy ear flap is unacceptably uncomfortable for the pet.
  • To maximize the ability of the ear flap to stand up straight after hematoma resolution or to prevent excessive scarring in the ear flap for cosmetic reasons.

What do we do to Relieve it? 

There are probably as many ways of correcting ear hematomas as there are veterinarians. Some veterinarians have good results using medical therapy, treating with a corticosteroid. Some veterinarians will use surgery or low-level laser therapy in the treatment regimen for aural hematomas. You and your veterinarian need to discuss the best way to treat your pet. The following are some of the commonly performed procedures.

Aspiration

This procedure involves simply using a syringe to remove the fluid contents from the hematoma. The problem is that a space is left behind when the fluid is removed, and this space readily refills with more fluid leading to only temporary results. The benefits of the aspiration method are that it is inexpensive and relatively easy to perform, but the disadvantages are that it may introduce infection and may require multiple attempts. If the clot in the hematoma is already well organized and on its way to scarring, there may not be much fluid left to aspirate, and the technique may not work at all. Usually, other methods are utilized.

Pie-Crusting Sutures

Here, an incision is made in the earflap surgically. The hematoma is drained of fluid and blood clots. To prevent the hematoma from refilling with fluid, multiple sutures are placed in the hematoma area either vertically or horizontally, either partly or completely through the earflap, with or without ear cartilage removal. Sometimes bandages are applied post-operatively, sometimes not. Sutures are generally left in place for three weeks to allow good scarring to take place so that refilling will not occur. The earflap is essentially quilted to close any space where fluid might refill.

Teat Cannula Placement

A teat cannula is a small device used in the treatment of udder inflammation in cows. It can be placed in the opening of the teat to allow drainage of milk or infected discharges. Teat cannulas can also be surgically placed in a dog’s aural hematoma if the earflap is large enough to accommodate the device. The hematoma is drained of fluids and allowed to heal over the next several weeks. This method is generally successful but does involve the dog tolerating a gadget inserted in its earflap for several weeks as well as accompanying fluid drainage.

What if there is a Concurrent Ear Infection?Usually, there is a reason why a dog has been shaking his head: an ear infection. This means that the ear infection must be treated along with the hematoma. The ear will need cleaning, a microscopic examination of the discharge, and medication. Sometimes ear shaking just happens and there is no underlying infection, but be prepared for the expense and trouble of treating an ear infection along with that of the hematoma.

What if We Leave it Alone?

If left alone, an ear hematoma will resolve by itself. The fluid will be re-absorbed back into the body and the earflap will no longer bulge. The problem is that a lot of scarring is associated with this process and the ear is often not cosmetically appealing afterward (i.e. it becomes a “cauliflower” ear). Resolution of a large hematoma can take several months during which it may be uncomfortable for the pet. If the patient is a poor anesthetic risk, it is certainly reasonable to forgo surgery. Corticosteroids, such as prednisone, can be used to reduce scarring.

Aural Hematoma in Cats

The situation in cats is somewhat more complicated than in dogs largely because the cartilage in the feline ear is more sensitive to inflammation and scarring is more severe. This makes the untreated hematoma more likely to form a permanently narrowed ear canal and long-term ear infection potential. Cats’ ear cartilage tends to experience more healing deformity than dogs’ ear cartilage and more curling and softening of the thinner pinnal areas is seen.

What this comes down to is that there is less leeway in letting the ear heal on its own in cats than dogs. Surgical repair is especially important as there is a greater tendency for a cat’s canal to narrow. That said, a more natural cosmetic appearance of the actual ear flap is harder to achieve in cat than dogs. It is more important to focus on the function.

As with dogs, a cat’s hematoma is generally brought about by ear infections and subsequent head-shaking. (In cats, most ear infections stem from ear mites but there are plenty of exceptions.) Bandaging is often used post-operatively as is the Elizabethan collar to protect the ear from being scratched. The cat will need confinement during a healing period of approximately 3 weeks.